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It works by targeting two hormone receptors in the brainGLP-1 and GIPwhich help regulate appetite and insulin secretion

PB-TURSO (sodium phenylbutyrate + taurursodiol) Slowed AlSFRS-R decline in the phase 2/3 CENTAUR RCT (basis for 2022 FDA approval) but failed in the phase 3 PHOENIX trial and was voluntarily withdrawn from U.S./Canada in 2024

although use of this for prognostication purposes is currently limited due to lack of large scale evidence (53)

& Rangel, J

Assoc., 161 (6): 714-719

Peptide Partners elected to have samples tested against label claim rather than batch-specific COA claim, and some score corrections were published in October 2025 after that policy clarification