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Common adverse reactions reported include nausea, diarrhea, vomiting, constipation, and stomach discomfort, which may detract from the overall treatment experience

It reduces your appetite and helps you feel fuller for longer, which means youre less likely to overeat or snack between meals

One notable difference: semaglutide and tirzepatide have established prescribing information with FDA-approved dose ranges and flexibility for clinicians to hold patients at intermediate doses if tolerability is an issue

This means there will be a period of overlap where both medications are pharmacologically active

McEwan P, Foos V, Palmer JL, Lamotte M, Lloyd A, Grant D

After starting, it takes about 4 to 5 weeks to reach steady-state levels in the body