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As an effect of ROS on the central nervous system (CNS), which has a high lipid content and high oxygen consumption, the oxidative agents promote lipid peroxidation, leading to membrane fluid loss, suppressing membrane potential, and increasing the accumulation of ions, particularly Ca 2+

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1.4.2 Evidence gap: metabolic proxies as insufficient substitutes for reproductive outcomes Despite the proliferation of guidelines and reviews regarding GLP-1RAs, the majority remain focused on metabolic syndrome, weight management, and cardiorenal protection