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GH SIGNALING Data on GHR signaling derive mainly from rodent models and experimental cell lines, although GH-induced activation of the JAK2/STAT5b and the MAPK pathways have been recorded in cultured human fibroblasts from healthy human subjects (57)

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Factors of the GH/IGF-1 axis known to influence ageing

Patients considering combination approaches should understand that this represents an unproven strategy that increases cost and injection burden without documented benefit

The result is not just reduced desire but potentially reduced physical responsiveness, a slower arousal process, and difficulty reaching climax even when desire is present