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Group differences between PD and controls stayed after the removal of confounds such as deep-brain stimulation (DBS), but differed across studies

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Glutamine, through conversion to glutamate and subsequently to -ketoglutarate (-KG), not only fuels the tricarboxylic acid (TCA) cycle for energy generation but also contributes carbon skeletons for lipid, carbohydrate, and nucleotide biosynthesis, thus sustaining the high metabolic demands of activated fibroblasts [8]

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