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Website Reference: Prevalence of Obesity. World Obesity Health Risks of Being Overweight. NIDDK, U.S

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In human specimens and OA models established via surgery such as the DMM model or ACLT, immunohistochemical or Western blot analyses of OA cartilage and synovial tissues show significantly lower GPX4 expression in lesioned areas compared to adjacent relatively normal tissues or normal control mice and patients

In addition, immunohistochemical analysis of tumor tissue sections also demonstrated that NP4 could increase the infiltration of CD8 + T cells (Fig

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