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Notably, in AKI and CKD, increased inflammation is widely associated with elevated ROS levels and reduced mitochondrial biogenesis, as evidenced by decreased markers such as PGC-1 (Chen et al

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2225 During cartilage destruction, pro-inflammatory cytokines like IL-1 have been shown to have catabolic effects

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

doi: 10.1056/NEJMcpc2300907 [PubMed] 37902356 Honor PM, Perriens E, El Helou M, Belhoussine Drissi S, Blackman S