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74 The enhanced oxidant stress in the mitochondrial matrix is then mainly derived from complex I and, to a lesser degree, from complex III, 71 and the oxidant stress and injury correlate with protein adduct formation in mitochondria

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Individual clearance varies based on body composition, kidney function, and liver function, but the Phase 2 trial established the mean half-life at approximately 6 days for the once-weekly subcutaneous dose range of 0.5mg to 12mg

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The federal Medicaid Drug Rebate Program (MDRP) requires states to cover nearly all Food and Drug Administration (FDA) approved drugs from rebating manufacturers, limiting states ability to control drug costs through restrictive formularies

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