Pickart, L., und Margolina, A
Glutathione can become easily depleted as it works to destroy free radicals and help to prevent the damage that they can cause to your cells which can lead to illnesses and premature aging
however, HCVHIV co-infection increases oxidative stress more potently than HIV mono-infection 124,125
However, a dysregulated increase in the level of these free radicals, as seen in mitochondrial diseases, can result in oxidative damage by overwhelming the cellular antioxidant defence mechanism, of which glutathione is the principal component [4]
Neurotherapeutics 19 (5), 16621685
Chronic alcohol consumption causes hepatic mitochondrial dysfunction and reduces ALDH activity, leading to acetaldehyde accumulation [25]