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Many polyphenols, including ellagic acid and quercetin, activate the AMP-activated protein kinase (AMPK) pathway, a master regulator of in vivo lipid synthesis, fatty acid catabolism, and oxidation

It is rapidly hydrolyzed in a weakly alkaline environment of tissues and after a short latency period, it acts for 60-90 minutes

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In hemodialysis patients, elevated levels of AOPPs have exhibited a positive correlation with plasma myeloperoxidase activity (74) and oxidized fibrinogen was identified as a principal molecule contributing to the positive chemical reaction to AOPPs (75, 76)

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