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The most commonly reported adverse events were mild-to-moderate headache and gastrointestinal effects including flatulence and mild diarrhea

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Evidence from animal and human studies shows that B 12 also has neuroprotective and anti-inflammatory properties,15 and intervention studies in humans have reported beneficial effects of better B 12 status or B 12 therapy in multiple sclerosis,16 Parkinsons disease,17 myalgic encephalomyelitis,18 autism,19 and (administering very high doses of methylcobalamin) in amyotrophic lateral sclerosis.20 Subcutaneous administration is sometimes recommended when intramuscular injections are contraindicated, for instance, in people using anticoagulants

Mitochondrial Biogenesis and Exercise: Lpez-Lluch, G., et al

2002, pp

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