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[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed

doi:10.4093/dmj.2023.0164 22

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That combination can make normal meals feel larger, heavier, and harder to finish

An unanticipated observation was that black C57BL/6-HGF mice produced spontaneous melanomas without ultraviolet exposure, although spontaneous melanomas were not found in albino C57BL/6-c-HGF transgenic mice and were rare in albino FVB-HGF mice 9

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