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Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism

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This makes perfect sense as erythrocytes take up large amounts of sphingosine and detoxify this sphingolipid by enzymatic conversion to sphingosine-1-phosphate by sphingosine kinase [124]

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The measurement was performed in three technical replicates and the blank averaged over all concentrations

Although it is difficult to conclusively prove a cause-and-effect relationship between the consumption of EDs and the observed pathophysiological abnormalities, most scientific evidence (mostly clinical case reports) indicates that both occasional and especially chronic use of EDs is associated with the occurrence of numerous adverse effects (AEs)