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In macrophages, spermidine activates mitochondrial superoxideAMPKHIF-1 signaling and autophagy, down-modulates costimulatory molecules, and polarizes cells toward an M2-like phenotype, thereby dampening antitumor responses [148, 149]

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Am J Cancer Res 7(12):23502394 Fu Z, Chen X, Guan S, Yan Y, Lin H, Hua ZC (2015) Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway

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Nguyen did alternative therapy and now my shoulder is back to the way it should be, without pain

And the only way to find it is through systematic experimentation over four to six weeks