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doi:10.1016/S0022-3565(25)03461-5

Ligand-mediated PNPs easily pass the BBB via receptor-mediated endocytosis, thus providing targeted delivery of therapeutics to the parenchyma of the brain

Another systemic strategy is the administration of antibodies (e.g., infliximab anti-TNF- in the treatment of recalcitrant ulcerating necrobiosis lipoidica) or peptides (e.g., neuropeptide -melanocyte-stimulating hormone -MSH)

Class-related terms like semaglutide and tirzepatide also rose

This genetic insight may help support more informed conversations with your provider about whether your maintenance dose aligns with your genetic predispositions, though genetics should be interpreted with a qualified healthcare provider and do not predict exact medication response

And when those are the goals, the focus shifts