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Your body evolved to defend against starvation, and significant weight loss triggers conservation mechanisms
Rosenberg VA, Eglinton GS, Rauch ER, et al
Tannenbaum, Steven R
CR-fed females showed upregulation of pathways including Lysine degradation, and Valine, leucine, and isoleucine degradation. Interestingly, DL-fed females had no significantly upregulated pathways, and indeed CR-fed females had upregulation of Valine, leucine, and isoleucine biosynthesis, while DL-fed females had downregulation of this same pathway
Accordingly, the Ca 2+ efflux response to GLP-1 was lower than that induced by glibenclamide, presumably because glibenclamide induces robust Ca 2+ influx by opening VDCCs
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