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However, annual review with your GP is advisable to: Ensure adherence to the injection schedule Monitor for any new or worsening symptoms Consider testing for other autoimmune conditions if symptoms develop (particularly thyroid function, as thyroid disease is commonly associated with pernicious anaemia) [2] Gastric cancer risk: Pernicious anaemia is associated with a slightly increased risk of gastric cancer

Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation

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BioPharma Trends, 41(5), 589-612

Xayaseng V, Phongluxa K, van Eeuwijk P, Akkhavong K, Odermatt P