Traditionally, a stepwise approach was advocated, in which a new agent is added to the existing regimen, but evidence is growing to support a more proactive approach in many, by combining glucose-lowering agents from initial diagnosis [6]
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Hepatocytes possess highly efficient counter-regulatory systems against oxidative effects such as cytochrome systems (CYP) P450, either by endogenous or exogenous substances, enzymes such as glutathione S transferase, the flow-through transporters, and molecules that contain thiol, such as Glutathione or Thioredoxin [68]
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3.2.2 Prebiotic effect Cereal glucan has recently been identified as a well-recognized bioactive carbohydrate with multiple functions and recommended as a potential prebiotic in recent studies
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