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Third, activation of AMPK is also associated with increased production of mitochondrial superoxide-derived radicals (ROS) and decreased activity of mitochondria 33,43

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In anovulatory PCOS granulosa cells, the synergistic effect of high insulin and LH levels may induce premature expression of LH receptors in small follicular subsets, leading to premature differentiation of granulosa cells and follicular growth stagnation [98]

Avoid applying directly with vitamin C serums or strong acids in the same step, as these may affect stability