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They are not, however, the same as controlled clinical trials in human subjects

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The soreness correlates with injection technique: reviews mentioning "slow injection over 30 seconds" report 28% less soreness than those describing "quick push" technique (pattern analysis from 340 reviews specifying technique)

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Sulkava R, Erkinjuntti T, Laatikainen T (1985) CSF -endorphin and -lipotropin in Alzheimers disease and multi-infarct dementia

AR affects approximately 10-40% of people globally [4], damaging labor productivity and causing economic losses of 30 to 50 billion euros per year in the European Union [5]