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Dimeric macrocycles act as Met agonists The intermolecular interaction of hHGF with the Met ectodomain triggers Met dimerization and activates downstream signalling via intracellular trans -phosphorylation 4

To further validate these findings using an orthogonal approach, rather than NMN treatment, we next used transgenic mice that globally over-expressed the NAD + biosynthetic enzymes NMNAT3 (Fig

Reduction of the infectivity of toxoplasma gondii and Eimeria stiedai sporozoites by treatment with bovine lactoferricin