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biosimilar developers reached settlement agreements with AbbVie allowing launch in January 2023 a date AbbVie chose, not a date dictated by any single patent expiry

Concomitant monitoring requirements (SUA levels and liver/renal function) impose additional burdens: frequent phlebotomy provokes patient resistance, while toxicity surveillance (ALT, AST, and creatinine) demands individualized schedules that increase healthcare encounters (Kaur et al., 2024

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Challenges include a protruding premaxilla and absent orbicularis oris in the prolabium ( Zhang , 2017)

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Peanut butter provides healthy fats