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In an additional embodiment the formulations or compositions described herein provide a therapeutically effective amount of at least one active pharmaceutical ingredient at the site of disease with no detectable systemic exposure

Biomarker analyses reveal systematic endocrine disruption, characterized by 28.5% testosterone suppression and 45.2% FSH elevation in exposed populations, indicating primary testicular dysfunction rather than hypothalamic-pituitary axis impairment

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Sunlight exposure also results in the production of serotonin and beta-endorphins, which promote mood enhancement and relaxation, relieve pain, and boost immunity