Together these observations are consistent with an important concept: microglia are the earliest responders to a primary multifocal myelin injury in the MS white matter, and importantly, this injury/response seems to precede lymphocytic infiltration, arguing against adaptive immune cells being the primary drivers of white matter injury
Jin XK, Zhang SM, Liang JL, Zhang SK,Qin YT,Huang QX,Liu CJ,Zhang XZ
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