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& Shao, C

The MIC-1/GDF15GFRAL pathway in energy homeostasis: implications for obesity, cachexia, and other associated diseases

2018;10(7):e2960

For example, it has been found that polydatin promotes mitochondrial biogenesis and protects against mitochondrial oxidative stress via the activation of Sirtuin-1-PGC-1 pathway and Sirtuin-1-Nrf2-ARE pathway in kidney diseases (Zeng et al., 2016

GLP-1RAs work by reducing the appetite and feelings of hunger, slowing the release of food from the stomach, and increasing feelings of fullness after eating

The 60.3% symptom recurrence rate after discontinuation confirms that ongoing treatment appears necessary for sustained benefit