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Effective systemic dose in pigs of 1.1 mg/kg (~75 mg in humans) showed no adverse effects, representing approximately 300-fold below toxic dose

Subsequently, a randomized, placebo-controlled, double-blind clinical trial was conducted on subjects with mild cognitive impairment (MCI), who drank 0.6 mM H 2 water (approximately 300 mL per day) for 1 year [39]

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