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However, taking coffee by mouth may be safer and more effective : blood caffeine levels were 3.5x higher after drinking coffee than after an enema in a trial on 11 people [35+, 36, 37, 38, 39, 40, 41, 42, 43, 44]

Back Laughton, NB, Macallum, AB (1 June 1932) 'The Relation of duodenal mucosa to internal secretion of the pancreas', Proceedings of the Royal Society of London

A clinical trial of sitagliptin in a small sample of patients with impaired glucose tolerance and mild T2DM found significant reductions in carotid intimal thickness in sitagliptin compared with diet control alone [122]

Heliyon 9(11):e21839 Bozic I, Savic D, Laketa D, Bjelobaba I, Milenkovic I, Pekovic S et al (2015) Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia