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Betaine supplementation has been used for over 40 years to support individuals with genetic defects of folate dependent remethylation because betaine is known to increase methionine concentration and aid homocysteine reduction

In p43-overexpressing mice, mitochondrial mass initially increases, but mitochondrial DNA content declines over time, impairing mitochondrial function

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The mechanisms allowing for this change between the 2 metabolic profiles will have to be elucidated in future studies

In reality, the treatment of underlying vector-borne infection leading to cyclical Herx flares may be the main issue

Lightly pat into the skin to aid in absorption