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Statements Author contributions XZ and MW mainly wrote and revised the manuscripts, and constructed the framework of the manuscript

In addition to astrocytes and oligodendrocytes, microglia have been shown to be involved in ALS pathogenesis (Beers et al., In vivo imaging studies demonstrated increased microglia activation and inflammatory activity in spinal cord during symptomatic stages in the SOD1 G93A mouse model (Dibaj et al., G37R mice (Boille et al., High calorie diets in ALS A number of studies have tried to correct the energy deficit using metabolic therapies in animal models and patients with ALS, with the hope that an improved metabolism can delay symptoms and extend survival in ALS (Dupuis et al., 2006, 2012

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Clustering is on its way and long distance prevention will have more to offer with many of these agents