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*Correspondence: Predrag Sikiric, [email protected] This article was submitted to Gastrointestinal and Hepatic Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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High-dose therapy may also cause a brief increase in blood pressure, though this usually returns to baseline within a few hours

In McCormick DB, Wright LD (eds.)

Its harmless and often used in ultra-high doses