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And here is something most people miss: aged cells generate more reactive oxygen species, and since melatonin acts as a potent endogenous antioxidant, the body consumes more of it to neutralize oxidative stress

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Theres also a clinical one

Environmental triggers of thyroiditis: hepatitis C and interferon-

What you should not do is run it 7 days/week indefinitely the receptor desensitization issue still applies