A 2014 double-blind placebo-controlled clinical trial (PMC4207440) showed topical GSSG (the oxidised form) did improve skin whitening markers in healthy women over 10 weeks
doi: 10.1007/s00418-014-1245-7 260 LiYHWangXPanYLeeDHChowdhuryDKimmelmanAC
The four agreement metrics were met (Table 2)

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A spokesperson for the company noted that gastroparesis is a known risk for people with diabetes and that "patient safety is of utmost importance to Novo Nordisk." Gastroparesis is not mentioned in the prescribing information for Ozempic or Wegovy, but delayed gastric emptying is mentioned for each drug
It obsoletes a way of deciding which drugs are worth developing