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Interestingly, biopsies from asthma patients support this observation, with reduced levels of RAMP1 compared to the controls ( Calcitonin-gene related peptide modulates the Th9 response (response related to TIHS), inducing the expression of GATA3 and PU.1 (transcription factor of Th9 cells) and IL-9 production, enhancing airway inflammation (Mikami et al., 2013)

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