I looked like a pint of Guinness! he wrote in the comments

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Low vitamin D levels have been linked to increased risk of heart diseases such as hypertension, heart failure, and stroke
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Your immune system is a complex puzzle
While some of the discrepancies in these results may be from our definition of M1 vs M2, which is a reductive approach to macrophage phenotyping, it is also likely that differences in dose, duration, constituent chemicals and other aspects of e-cigarette delivery are responsible, as well as altered cellular responses in the setting of signaling from other cells in vivo