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However, achieving meaningful systemic levels via oral delivery is very challenging

Modulation of GABAergic neurotransmission, including receptor expression, by probiotics following ES-induced depression has been shown [72, 84]

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Gastrointestinal adverse events were predominantly limited to initial dosing, while dose escalation resulted in lower discontinuation rates owing to these adverse events than among patients who remained on the starting dose

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But for many people, no matter what they eat, indigestion or heartburn is inevitable