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So if we were to inhibit the SLC33A1 transporter, the GSSG would accumulate, and the cancer cells would die. Our work demonstrates that defining how nutrients and metabolites are transported across cellular and organelle membranes reveals fundamental principles of cell biology while uncovering a major class of disease-relevant and therapeutically tractable proteins, Birsoy says

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A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells

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Interestingly, the weight loss effects were not dose-dependent, as a higher dose of 10mg/daily AOD-9604 did not correspond to greater weight reduction [1]