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For a plain-language summary of growth hormone physiology and its role in body composition, sleep, and tissue repair, a peer-reviewed Nature Reviews Endocrinology paper examining the role of the growth hormone / IGF-1 axis in obesity, adult body composition, and metabolic regulation is a strong starting point

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More specifically, the amino acids which are replaced appear to be the 2nd, 8th, 15th, and 27th amino acids