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All potential benefits therefore must be weighed cautiously, and treatment is undertaken under medical supervision given that safety and efficacy are not yet established by regulatory authorities

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doi: 10.1007/BF02978833

Management depends on B12 supplementation, either via high-dose oral routes or via parenteral administration

B12 deficiency can impair this process, leading to neurological problems such as memory loss, cognitive decline, and difficulty concentrating

The exact mechanism remains unresolved after decades: no specific receptor, precursor gene, or biosynthetic pathway has been definitively identified