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A UT Southwestern study published in JAMA Network Open in March 2026 found that only 25% of patients remained on any GLP-1 receptor agonist one year after starting therapy

In humans, fasting systemic plasma concentrations of total GLP-1 (including metabolites generated by DPP-4-mediated degradation) are typically in the range of 510 pmol/L and can increase up to 40 pmol/L in response to a meal [236]