GPx7 likes to interact with the domain of PDI, and intramolecular cooperation between the two redox-active sites of PDI increases the activity of the Ero1/GPx7/PDI triplet, thereby promoting protein folding mechanisms (Wang et al., 2014) (Figure 6)
Nat Rev Dis Prim
Poor safety standards or lack of regulatory oversight: Some creams are unregistered or not dermatologically tested, increasing risk of irritation, allergic reactions, or worse
Topical glutathione Creams, lotions and glutathione-based peels that act at the application site
Typical agents include chloroacetophenone (CN) commonly known as Mace, chlorobenzylidene malononitrile (CS), oleoresin capsicum (OC) called pepper spray, and diphenylaminochloroarsine (DM) or Adamsite
In addition to glutathione, this formulation works on the SLC24A5 pathway, a key factor involved in skin pigmentation, to support stronger and more consistent whitening results