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Rats received AOD 9604 daily for 6 months and cynomolgus monkeys for 9 months

Side Effects of B12 Injections While B12 injections are generally safe, they may cause side effects in some individuals

This matters for dosing because beta-3 receptor sensitivity varies throughout the day and in response to nutritional status

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Increased intestinal permeability is facilitated by a high-fat diet (HFD) 22 , and may allow for bacterial translocation from the gut to adipose tissue 23