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Clatworthy AE, Pierson E, Hung DT

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in the second Trump administration, the FDA has rarely convened the panels of outside advisers frequently used in the past

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The TME is characterized by nutrient deprivation, hypoxia and an acidic milieu, driven by aberrant tumor vasculature and the Warburg effect (a preference for aerobic glycolysis even in the presence of oxygen), which collectively facilitate immune evasion by tumor cells (88,89)