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CRF-containing neurons from PVN project within NTS, where CRF receptors have been demonstrated as well as to the area postrema ( CVS could be the consequence of a dysfunctional allostasis, defined as the physiologic adaptive changes activated by acute and chronic stressors for preserving the body homeostasis ( Gastric Dysmotility Gastric motor abnormalities have been suggested to play a key role in CVS pathogenesis

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Treatment sessions can be repeated several times a week or several times a month, depending on the patient's condition