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In STZ-treatment rats, Exendin-4 improved learning and memory performance, protected hippocampal neurons against degeneration, and reversed STZ-induced tau hyperphosphorylation through downregulation of GSK-3 activity (154, 155, 182)

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For retatrutide at 4,895 daltons, these comparisons suggest that nasal delivery is feasible but will require optimization, that brain delivery effects may be achievable at doses lower than needed for full systemic effect, and that absorption variability will be higher than with injection

We don't know the allergy's precise etiology

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