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Synaptic changes induced by melanocortin signaling

In the reporting, patients with the highest BMIs (the most overweight) taking the highest dose of Trulicity (4.5 mg) experienced the most weight loss

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What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis