Combining carboplatin with the ROS-inducing compound sulfasalazine reduces the carboplatin IC 50 in TNBC [54], further supporting the therapeutic strategy of glutathione depletion to enhance chemotherapy efficacy [19]
10.3390/ijms21134777 [DOI] [PMC free article] [PubMed] [Google Scholar] 243.Ding Y, Zhang B, Zhou K, Chen M, Wang M, Jia Y, et al
While a new episode could be triggered by GLP-1 RAs, this relationship needs to be established by future studies
Evidence demonstrates that acute glucose fluctuation forms the stress that alters microglial activity (eg, inflammatory activation or self-degradation), which may be one of the mechanisms of cognitive deterioration in diabetic patients.91 Diabetic mice also show astrocyte changes in the hippocampus.92,93 Since astrocytes are important neuronal support cells, astrocyte changes may aggravate the dysfunction of neuronal function
For decades, the clinical consensus on weight loss was clear: slow and deliberate produces better outcomes than rapid
205 Following carboplatin treatment, ACSL1/FSP1 activation inhibits ferroptosis and reduces the sensitivity of cancer cells to platinum chemotherapy, promoting cell survival and metastasis
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