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GLP-1 medications like semaglutide work by mimicking glucagon-like peptide-1, a hormone that slows stomach emptying, reduces appetite signals in the brain, and improves pancreatic insulin release

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43 The relevance of this pathway for tumorigenesis is demonstrated by the fact that humans with the Laron syndrome, a recessively inherited defect in the growth hormone receptor, display extremely low IGF-1 and reduced insulin concentrations and usually do not develop cancer despite high prevalence of obesity and dyslipidemia

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Wegovy or Ozempic can be tools for weight loss, but maintaining progress comes down to sustainable lifestyle changes