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Discussion There is an exponential increase in publications suggesting that drug-induced liver injury, especially APAP hepatotoxicity, involves ferroptosis

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The mechanism is indirect: improved energy supports adherence to diet and exercise, and lipotropic agents support liver fat metabolism

People of thiamin deficiency include those affected by: pregnancy chronic illness inadequate dietary intake alcoholism bariatric surgery chronic diuretic therapy Prolonged, untreated thiamin deficiency may lead to Wernicke-Korsakoff syndrome, a disorder that can affect people with chronic alcoholism, gastrointestinal disorders, or AIDS

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