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GHK-Cu a naturally occurring copper-binding peptide has changed that

Eli Lilly reported dysesthesia was "generally mild" and "rarely led to discontinuation." TRIUMPH-1 the larger general obesity trial with 2,339 patients at 80 weeks confirmed dysesthesia also occurs outside the osteoarthritis population, though at a lower rate than in TRIUMPH-4

Trends in Molecular Medicine , 28(7), 542-556

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We hope that by highlighting the potential of weight loss drugs to help with binge eating symptoms, our findings will lead to further funding of larger high-quality studies in this area, to better understand how this medication could be used in practice and improve treatment options. Dr Costantini said: One strength of our study is the involvement of a lived experience panel, who shared important insights into their views and concerns about the use of these medications for binge eating, as well as the challenges many people face in accessing treatment for binge eating disorder