Concomitantly, we measured increased pyruvate levels in mutant compared to control cells (Supplementary Fig
174,175 Several oncogenic mechanisms, such as the transcription factor HIF-1, PI3K/Akt/mTOR pathway and c-Myc, upregulate genes encoding glucose transporters and glycolytic proteins, including GLUT1, GLUT3, and lactate dehydrogenase (LDH)
However, especially under high stress from environmental influences, sports, or illness, the glutathione level can decrease
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S., Alaqil, A
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